Faculty

Zhao, Xiaohu     


Research direction: Chemical Biology(bioorthogonal chemistry);Organic Synthesis

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Associate Professor of Chemistry    


Education And Academic Experience

2019.4-present Associate Professor, College of Chemistry, Sichuan University, Chengdu, China

2017.8-2019.8 Postdoctor, Division of Chemistry & Biological Chemistry, Nanyang Technological University, Singapore (with Prof. Jianrong Steve Zhou)

2016.7-2016.11 lecturer., College of Chemistry and Chemical Engineering, Shaanxi University of Science & Technology

2011.9-2016.6 Ph.D., College of Chemistry, Sichuan University, China (with Prof. Xiaoming Feng)

2007.9-2011.6 B.Sc., College of Chemistry, Sichuan University, China


Publications:

1. Jingshuo Gao, Qin Xiong, Xueting Wu, Jiajie Deng, Xiaocui Zhang, Xiaohu Zhao, Pengchi Deng* and Zhipeng Yu*, "Direct ring-strain loading for visible-light accelerated bioorthogonal ligation via diarylsydnone-dibenzo[b,f][1,4,5]thiadiazepine photo-click reactions", Commun. Chem. 2020, 3, 1-10

2. Jiajie Deng, Xueting Wu, Guiling Guo, Xiaohu Zhao and Zhipeng Yu*Photoisomerization-enhanced 1,3-dipolar cycloaddition of carbon-bridged octocyclic azobenzene with photo-released nitrile imine for peptide stapling and imaging in live cells, Org. Biomol. Chem., 2020, 18, 5602-5607.

3. Xiaohu Zhao, Haiyan Xu, Xiaolei Huang and Jianrong Steve Zhou*, "Asymmetric Stepwise Reductive Amination of Sulfonamides, Sulfamates and a Phosphinamide via Nickel Catalysis" Angew. Chem. Int. Ed, 2019, 58, 292-296. Highlight by Synfacts 2019, 15(03), 0258.

4Xiaohu Zhao, Hongjiang Mei, Qian Xiong, Kai Fu, Lili Lin, Xiaohua Liu and Xiaoming Feng*, "Highly enantioselective construction of carbazole derivatives via [4+2] cycloaddition of silyloxyvinylindoles and β,γ-unsaturated α-ketoesters" Chem. Commun., 2016, 52, 10692–10695.

5. Xiaohu Zhao, Xiaohua Liu, Hongjiang Mei, Jing Guo, Lili Lin. Xiaoming Feng*,"Asymmetric Dearomatization of Indoles through Michael/Friedel–Crafts-Type Cascade to Construct Polycyclic Spiroindolines", Angew. Chem. Int. Ed, 2015, 54, 4032–4035.

6. Xiaohu Zhao, Xiaohua Liu, Qian Xiong, Hongjiang Mei, Baiwei Ma, Lili Lin and Xiaoming Feng*, "The asymmetric synthesis of polycyclic 3-spirooxindolealkaloids via the cascade reaction of 2-isocyanoethylindoles" Chem. Commun., 2015, 51, 16076–16079.

7. Xiaohu Zhao, Mingsheng Xie, Xiaohua Liu, Yulong Zhang, Xiao Xiao, Lili Lin, and Xiaoming Feng*, "Chiral N,N′-Dioxide–Yttrium Triflate Complexes-Catalyzed Asymmetric Aldol Cyclization of α-Keto Esters with α- Isothiocyanato Imide", Adv. Synth. Catal, 2013, 355, 3253–3262.

8. Xiaoxia Wu, Mingsheng Xie, Xiaohu Zhao, Xiaohua Liu, Lili Lin, Xiaoming Feng*, Enantioselective fluorescent sensor for amino acid derivatives basedon BINOL bearing hexahydropyrrolo[1,2-c]imidazol-1-one units. Tetrahedron. Lett., 2014, 55, 3446–3449 .

9.Hongjiang Mei, Xiao Xiao, Xiaohu Zhao, Bing Fang, Xiaohua Liu, Lili Lin and Xiaoming Feng*, "Catalytic Asymmetric Henry Reaction of Nitroalkanes and Aldehydes Catalyzed by a Chiral N,N-Dioxide/Cu(I) Complex. J. Org. Chem. 2015, 80, 2272-2280.

10.Qian Xiong, Lili Lin, Xiaohu Zhao, Jiawen Lang, Xiaohua Liu, and Xiaoming Feng*, "Zinc(II)-Catalyzed Asymmetric Diels–Alder Reaction of (E)-1-Phenyl Dienes with β,γ-Unsaturated α-Ketoesters. J. Org. Chem. 2018, 83, 12527-12534.

11.Yulong Zhang, Xiaohua Liu, Xiaohu Zhao, Jianlin Zhang, Lin Zhou, Lili Lin and Xiaoming Feng*, "Enantioselective Friedel–Crafts alkylation for synthesis of 2-substituted indole derivatives" Chem. Commun. 2013, 49, 11311-11313.

12.Yan Lu, Min Wang, Xiaohu Zhao, Xiaohua Liu, Lili Lin, Xiaoming Feng*, "Cooperative Chiral Guanidine/AgPF6Catalyzed Asymmetric Isocyanoacetate Aldol Reaction with Isatins" Synlett., 2015, 26, 1545-1548.

13. Xiao Xiao, Hongjiang Mei, Quangang Chen, Xiaohu Zhao, Lili Lin, Xiaohua Liu and Xiaoming Feng* Direct asymmetric vinylogous Michael addition of 3-alkylidene oxindoles to chalcones catalyzed by a chiral N,N-dioxide ytterbium(III) complex. Chem. Commun., 2015, 51, 580—583.

14. Yin Zhu, Mingsheng Xie, Shunxi Dong, Xiaohu Zhao, Lili Lin, Xiaohua Liu and Xiaoming Feng*, "Asymmetric Cycloaddition of β,γ-Unsaturated α-Ketoesters with Electron-Rich Alkenes Catalyzed by a Chiral Er(OTf)3/N,N′-Dioxide Complex: Highly Enantioselective Synthesis of 3,4-Dihydro-2H-pyrans" Chem. Eur. J. 2011, 17, 8202–8208.

15. Mingsheng Xie, Xiaohua Liu, Yin Zhu, Xiaohu Zhao, Yong Xia, Lili Lin and Xiaoming Feng*, "Asymmetric Synthesis of Tetrahydroquinolines with Quaternary Stereocenters through the Povarov Reaction" Chem. Eur. J. 2011, 17, 13800-13805.

16. Zuliang Zhang, Xiaohua Liu, Zhen Wang, Xiaohu Zhao, Lili Lin, Xiaoming Feng*, "Chiral Co(II) complex catalyzed asymmetric Michael reactions of ß-ketoamides to nitroolefins and alkynones" Tetrahedron. Lett., 2014, 55, 3797-3801.

17. Xiaoyu Hao, Xiaohua Liu, Wei Li, Fei Tan, Yangyang Chu, Xiaohu Zhao, Lili Lin and Xiaoming Feng*, "Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions of Disubstituted Ketenes for Synthesis of ß-Lactones and δ-Lactones" Org. Lett. 2014, 16, 134−137

 

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